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doi: 10.1186/s43088-022-00196-1

36 , 37 Finally, c-Myc expression is often elevated in the resistant fraction following cisplatin treatment, as it not only promotes survival through the acquiring of chemo-resistance genes and upregulation of DNA repair proteins, but also has been found to be stabilized in certain cancers by chemo-induced gain or loss of micro-RNAs (miRNAs, such as miR-145) that target c-Myc

2020 Sep 30;8(10)

The most common inclusion criterion for performing the surgical treatment is that 12 months must have elapsed from the onset of symptoms and evidence of stable curvature for at least 3 months 6

The specific molecular mechanisms may require more refined redox assays and more rigorous experimental designs for further exploration