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Without adequate P5P, the AADC enzyme cannot function, creating a secondary bottleneck that halts serotonin production regardless of how much 5-HTP is available
A Japanese clinical review showed significant electrophysiological improvement in neuropathy patients treated with methylcobalamin (Tokuda et al., 2018)
doi: 10.3390/ijms25126697 150 MorandiSCHerzogELMunkMKreuzerMLargiadrCRWolfSet al
That brings us to the next section: the why
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