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10.1016/B978-0-323-44887-1.00053-5 42 DaviesJ
Xue and colleagues found that the transsulfuration pathway provides a novel mechanism for cells to obtain essential components for GSH synthesis by degrading methionine into cysteine to maintain GPX4 activity (81)
Beyond direct antioxidant activity, glutathione functions through several enzymatic systems central to detoxification and redox control, including glutathione-S-transferases for conjugation reactions, glyoxylases, glutathione peroxidases and peroxiredoxins for peroxide reduction, and glutaredoxins for thiol-disulfide exchange
These findings are supported by a critical review of the literature [49]
10.1016/j.mcn.2012.07.004 34 HanX.SunS.SunY.SongQ.ZhuJ.SongN.et al (2019)
