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For the 1723 fragment, researchers should consider whether the observed effect could be driven by counter-ion, pH, impurity, endotoxin, degradation, aggregation, solvent, or assay interference

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Both peptides show favorable safety profiles in preclinical studies

Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form

Patients who understand that the GH-IGF-1 cycle operates on a 4 to 8 week minimum timeline, and that cumulative results build over 3 to 6 months of consistent protocol adherence, are the ones who complete a full cycle and achieve meaningful body composition change