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Concurrently, microbial regulation of host tryptophan metabolism occurs through serotonin synthesis and kynurenine pathway modulation(Roager and Licht, 2018)

In addition, intestinal glutathione-S-transferase (GST) can catalyze the same reaction ( Gut microbiota-produced erucin is metabolized similarly to SFN, as shown in Figure 2

There is some evidence to suggest that patients receiving methotrexate, commonly used in rheumatoid arthritis, are at increased risk of nonmelanoma skin cancer, possibly due to the photosensitizing nature of methotrexate

doi: 10.1105/tpc.105.033589 50 Friedmann AngeliJ

Nicotinamide is released from NAD by hydrolysis in the liver and intestines and is transported to other tissues
