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Mechanism of Action: The FOXO4-p53 Axis In senescent cells, the transcription factor FOXO4 is upregulated and stabilized via the CHK2-USP37 axis, where the deubiquitinase USP37 prevents its proteasomal degradation (PNAS, 2026)

Neurobiol Dis 16:468477 Arriza JL, Dawson TM, Simerly RB et al (1992) The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain