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The overstimulation of non-NMDA receptors results in the rapid cell death, while overstimulation of NMDA receptors leads to a loss of cellular processes (Deng and Poretz, 2003
Iron metabolism: The catalyst of death Although iron is an essential trace element for life, its dyshomeostasis is a key catalyst for ferroptosis
Helicases and helicase-associated ORFs (8 ps/gps), including primase (1 ps/gp), and gyrase subunits A and B (2 subunits), are associated DNA replication with ps154/ps156 ( gyrase A/B ) and ps123/ps125/ps128/ps201 (Helicases) present in the proteomics data (Supplementary Table 1

Clinical trials have further underscored the potential of TRAIL-R2 as a therapeutic target
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes