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Venous blood samples were obtained just before dosing and 20, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 10 and 12 h after the administration of NAC 600 mg

Therefore, it was concluded that the used treatments were not cytotoxic at the conditions (concentrations and incubation times) used in the study

2628 Recent publications critiquing ELISA-based 8-OHdG methods suggest that ELISA-based values tended to be higher values than gold-standard LC/MS-based measurement

Intracellular iron is stored in two major formsan unstable intracellular free ferrous iron pool and an inert form bound to ferritin ( 2 can trigger the Fenton reaction, producing ROS ( 4.2.2 Iron metabolism Transferrin-bound trivalent iron binds to the transferrin receptor (TFR1), allowing direct cellular entry through endocytosis and converts it to ferrous iron through STEAP3

Ketone esters are more effective than ketone salts at increasing serum ketone levels without exposing patients to the high sodium content of ketone salts [111]