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doi: 10.1126/science.1072221

conclusively demonstrated that MET orchestrates the transcription of PD-L1 through the activation of the downstream STAT1 pathway in pancreatic cancer cells [134]

A further increase in the level of oxidative stress could ultimately trigger a cytotoxic response originating in the mitochondria and lead to cellular apoptosis or necrosis (Figure 2)

Yamada &Lieber, 1984) and an increase in fluidity was also observed in plasma membranes isolated from Reuber H35 rat hepatomacells (Polokoff et al, 1985) or WRL-68 human hepatic cells (Gutierrez-Ruiz et al, 1995) following a long term treatment with ethanol (3 or 4 weeks)

"Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine"
