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By scrutinizing over 900 autopsy records of patients carrying different types of primary cancers, Stephen Paget was astonished in finding a discrepant pattern between the relative blood supply and the metastatic frequency of cancer cells to certain organs, i.e., there may exist a non-random distribution of metastatic cells to bones and visceral organs
doi: 10.1007/BF02539413 265 DonaldsonPJGreyACMaceo HeilmanBLimJCVaghefiE
Environ Health Perspect 120:608615, 2012a
Thus, Fe-S cluster binding in SLC25A39 highlights the metabolite-sensing potential of these cofactors
