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In addition, while our untargeted metabolomics approach provided a comprehensive overview of metabolic alterations, more refined techniques, such as targeted fluxomics or lipidomics, may yield deeper insights into lipid processing and redox cycling

These abnormalities involve the following aspects: increased inflammatory responses, such as matrix catabolism induced by interleukin-1 (IL-1 ) and TNF , as well as impairment of chondrocyte growth and anabolic responses, excessive oxidative stress, apoptosis of chondrocytes, and calcification of the cartilage matrix (112, 119)

FOXM1 is overexpressed in several cancers including breast, liver, colorectal, lung and the prostate [106]

The acetal linkages in the micelles remained stable at neutral pH but underwent rapid hydrolysis at pH 5.0 and 4.0, which resulted into disassembly and drug release not only in mildly acidic endosomal compartments but also in the highly reducing cytoplasm and cell nuclei 146

Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C
