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Description
CB1R mostly resides in the central nervous system (CNS) while the CB2R receptors are mostly expressed in the immune cells such as natural killer cells, neutrophils, and monocytes as well as other tissues such as the bladder, intestine, etc

Its absence is a red flag

in A Case-Based Guide to Clinical Endocrinology (ed Davies, T.F.) 4353 (Springer International Publishing, 2022)
Never discontinue prescribed B12 treatment without medical advice, as untreated deficiency can lead to serious complications
Let me explain: How to Diagnose and Check for Vitamin B12 Deficiency The problem comes down to diagnosis
