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This regulatory role of BPC 157 (BPC 157/ Egr1 ) may be related to other BPC 157 interactions including BPC 157/ Akt1 (elevated Akt1 expression in stroke rats, but unchanged expression in inferior caval vein ligatedrats (Vukojevic et al., 2018)), BPC 157/ Kras , BPC 157/ Src , BPC 157/ Foxo , BPC 157/ Srf , BPC 157/ Vegfr2 , BPC 157/ Nos3 , and BPC 157/ Nos1

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Despite the modest effects for sorafenib treatment observed in terms of improved PFS, subsequent clinical trials failed to confirm the survival advantage for the drug in breast cancer treatment

Therefore, exploring which chemotherapy regimens can effectively prolong their survival and improve the quality of life by combining apatinib has become a current research focus for advanced GC patients who have failed chemotherapy