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On one side are well-meaning scientists and advocates who feel strongly that powerful and potentially dangerous drugs should be clinically tested in human trials before theyre set loose in the marketplace

Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

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