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The reactive changes are dominated by mononuclear, predominantly macrophage, infiltration of hepatic portal areas, myocardium, spleen, and lymph nodes, which is reflected grossly in enlargement, nodularity, and mottling of the liver and enlargement of spleen and lymph nodes

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doi: 10.3389/fmolb.2019.00091 114 Al-SowayanNS