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Among the top 50 hits (proteins most enriched by LaccID in TCR-T cell coculture versus monoculture) were 33 proteins with direct literature links to CD8 + T cell activation, another 3 proteins with indirect links, 2 membrane proteases (ADAM19 and FURIN) and 8 mitochondrial proteins (Fig

To date, these either include a combination of multiple anti-angiogenic agents or a combination of anti-angiogenic drugs and other treatment regimens

To further explore the inflammatory state in the brain, we measured the mRNA levels of TNF-, IL-1, and IL-6 in SNpc by qPCR (Fig

However, these mainly utilised chemical assays, or at best UV-liquid chromatography quantification, to estimate tissue ET levels, methods which lack sensitivity and specificity 12

The rapid growth of cancer cells leads to increased requirements for blood flow at the tumor site and the subsequent abnormal angiogenesis has been shown to compromise BBB integrity (204)