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Molecular spectrum of TSH subunit gene defects in central hypothyroidism in the UK and Ireland

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Introduction Autoimmune diseases affect an estimated 15 million individuals in the United States and represent a significant burden of chronic morbidity ( Autoimmune diseases are widely recognized as multifactorial, arising from a complex interplay of genetic predisposition, environmental triggers, and immune dysregulation ( Sex-based differences represent one of the most consistent and striking features of autoimmune disease epidemiology, with female accounting for nearly 80% of all cases ( Environmental exposures also play a pivotal role in triggering or modulating autoimmune responses

However, the inventors also suggested that the peptide could be used not only to treat MS itself, either alone or with concomitant corticosteroid therapy, but also to prevent relapse or to treat MS in remission