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doi: 10.1016/1359-0197(92)90171-B

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In high-dose groups, researchers observed manageable but measurable proximal tubule lesions

Regarding the enzymes internal structure, the PSB loop is composed of the conserved amino acid residues 52 TYPKSGT 58 , of which the residues Lys 55 , Ser 56 , Gly 57 , and Thr 58 are involved in binding the 5-phosphate of PAP/PAPS

The small sample size of the control group due to our unequal randomization resulted in wide variability in the control group, ultimately limiting our ability to assess for true causal relationships by adequately testing for between-group differences