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Triphosphopyridine Nucleotide Oxidase-3 The NOX family of ROS-generating NADPH oxidases consists of 7 members: NOX1 to NOX5, DUOX1 and DUOX2

Phylum-level analyses indicate predominant Firmicutes with relative Bacteroidetes reduction in some studies (264, 265), while others report increased Actinobacteria , Verrucomicrobia , or pro-inflammatory Proteobacteria , alongside potential reduction of beneficial Bacteroidetes and Actinobacteria ( 262, 266)

Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

Furthermore, the urothelium also shows reduced cell growth and heightened cell permeability (Kiuchi et al., 2009)

Li XY, He WL, Wu G