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1 Introduction Numerous scientific studies have confirmed the role of diet in maintaining the proper functioning of the human body and in the prevention and treatment of various diseases, including obesity, diabetes, and cardiovascular disease ( 2 History of the ketogenic diet The earliest reports on the use of a low-carbohydrate diet to reduce the severity of symptoms, especially epileptic seizures, date back to antiquity ( In 1911, French doctors Guelpe and Marie published the first scientific report on the benefits of intermittent fasting in epilepsy (30)

A previous report found that loss of Fe-S cluster synthesis exacerbated erastin-induced ferroptosis in A549 cells due to an accumulation of iron 56

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doi: 10.1126/science.abq5916