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For complex biological matrices, LC-MS/MS is preferred due to its high sensitivity and specificity, allowing for the detection of lysine and its metabolites without extensive derivatization by using HILIC columns or ion-pairing chromatography to handle the molecules high polarity

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Neurotoxicol Teratol 33(6):721726 Chen PY, Hou CW, Shibu MA, Day CH, Pai P, Liu ZR, Lin TY, Viswanadha VP, Kuo CH, Huang CY (2017) Protective effect of co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts