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On the other hand, Eggers and colleagues could methodologically create a precise and controllable GDNFgradient, which has supported nerve regeneration (Eggers et al., 2019)

These mechanistic insights point to the SNARE complex as a vulnerable target of Pb neurotoxicity and warrant further research into how Pb affects its structural and regulatory components in glutamatergic neurons

however, clear demonstration of their efficacy in melasma has to be done [6]

For the research community this means that clinical doses and durations are not validated , most of todays research protocols rely on animal models and hypothetical extrapolations

I think of them like the battery in your car