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In brief, SGC-enriched cell cultures were obtained from DRGs harvested from adult female BALB/cAnNRj mice euthanized using 5% isoflurane followed by decapitation

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NAD), we likened the salvage pathway to a donut shop: any dough that isnt cut to shape can be kneaded back together and rolled out again, all while fresh dough is being turned out

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Thus, our results not only have potentially important mechanistic implications in how both the oxidative and antioxidant arms of redox homeostasis cooperate to regulate cell survival and death, but also provide a promising therapeutic strategy for cancer patients harboring oncogenic RAS that warrants further translational and clinical investigation