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Figure 2 Pathological Effect Caused by PDH Imbalance As a critical node in metabolic regulation, PDHC converts pyruvate to acetyl-CoA in mitochondria, and its inhibition leads to early metabolic reprogramming in response to sepsis, resulting in the accumulation of lactic acid, the aggravation of inflammation, the remodeling of TCA cycle, and the disorder of lipid metabolism, and the consequence of lower ATP synthesis relative to ATP demand

References Florsheim, E

[DOI] [PubMed] [Google Scholar] 81.Kakoli D and Rosalin N, Advances in Colorimetry, IntechOpen, Rijeka, 2023, p

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