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CB-839 exhibits increased cytotoxicity against cancer cell lines with high-GLS1 expression (such as HCC 1806) by decreasing GSH production (Hong et al., 2022)

10.1074/jbc.M511635200 J

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Its defining pharmacological feature is negligible cortisol and prolactin co-stimulation at GH-stimulating doses, making it the preferred compound in research protocols where isolated GH-axis stimulation is required

In comparison with DFO, patients treated with DFP exhibit more pronounced improvement in cardiac T2* values (123), higher left ventricular ejection fraction (123, 124), stronger cardiac protective effects (125), and a higher 5-year survival rate without heart disease (122)