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While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases

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Tumor heterogeneity and unpredictable mutations, such as single nucleotide polymorphisms, often lead to the failure of neoantigen-based cancer vaccines

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from Johns Hopkins University School of Medicine

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and later, in the 1980s, it was discovered that NAC can help prevent toxic reactions to chemotherapeutic agents

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