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Pharmacological or genetic glutaminase regulation along with oxidative chemotherapy can help to improve the design of combination strategies that escalate the rate of therapeutic success in cancer patients.

Aims/hypothesis Barth syndrome is a mitochondrial disorder caused by Tafazzin (TAZ) mutations, which impair cardiolipin remodelling and contribute to systemic metabolic alterations

The enzyme hydroxyacid-oxoacid transhydrogenase (HOT) (B) oxidizes gamma-hydroxybutyric acid, a potentially toxic metabolite, to succinic semialdehyde,