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However, GH can also exert metabolic actions independent from IGF-1 generation in the liver via activation of the phosphoinositide 3-kinase (PI3 K) and IRS pathways [98]

At low or moderate doses, also called physiological doses, which are those we would get through food (although we could also include B12 provided by fortified foods or supplementation in very small amounts), absorption depends on the intrinsic factor secreted and the intestinal receptors of the Castle complex, which regulate absorption

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