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10.1016/j.phymed.2024.155636 99 DavisA
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It also seems to have a signalling role, and can decrease wrinkle depth, Im guessing through hydrating the skin

Numerous studies have validated that the paracellular permeability ratio is greater in patients with Crohns disease and some of their clinically normal relatives [35, 36] and in patients with celiac disease [37] as compared with people unaffected by or unrelated to these disease states
