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This ROS increase causes mitochondrial membrane depolarization (m collapse), opens the mitochondrial permeability transition pore (mPTP), releases cytochrome c into the cytosol, and activates caspase-9 and caspase-3, culminating in intrinsic apoptosis (Nideliolu, 2025)

Conclusion and outlook Thiol-based redox systems arose early in evolution among all phylogenetic branches, a finding that was long proposed to reflect the necessity of organisms to defend themselves against the constant threat of molecular oxygen-mediated ROS production and damage

doi: 10.1186/s13008-024-00127-9 45