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We quantitatively frame its hormetic behavior (a biphasic dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition) and mechanistically explain its synergistic potential with conventional therapies

Rights and permissions About this article Cite this article Sanderson, S.M., Gao, X., Dai, Z

Luteolin, a natural flavonoid found widely in fruits and vegetables, promotes ferroptosis via GSH depletion and ROS accumulation through Fenton reactions (175)

In PD models, resveratrol and related polyphenols protect neurons via antioxidant effects (scavenging reactive oxygen species) and by activating cellular defense enzymes [14, 33]