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Ms recientemente, la enzima NNMT emergi como diana metablica en el tejido adiposo, y 5-Amino-1MQ se desarroll como inhibidor selectivo para estudiar cmo la metilacin de nicotinamida afecta el pool de NAD+ y SAM

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Histological analysis of adipose tissue from 5-Amino-1MQ-treated animals reveals increased presence of multilocular brown-like adipocytes, increased mitochondrial density, elevated expression of UCP1 and other thermogenic markers, and reduced adipocyte size