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doi: 10.3389/fonc.2023.1123420

Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

Being closely related to obesity, a new term has emerged in recent years: Diabesity, considered a modern epidemic, which indicates the coexistence of both diabetes and obesity [23]

In particular, long-term supplementation with 1000 mg/day for 6 months increased glutathione levels in the plasma, red blood cells, and oral cells, with no reported serious adverse effects [55]