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Although GSH is not alone responsible for these protective mechanisms, the hepatic production of GSH seems to be essential to survival, with knockout mice dying within months secondary to inflammation and hepatic steatosis resulting in liver failure [21]

For most peptides, the PK and PD timescales are tightly linked: when serum concentration falls, effect diminishes

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Several patents are available for drug delivery via the nasal route to either directly target the CNS, or by systemic transport of the drugs by the nasal route to target the CNS

Methods Materials LC/MS-grade methanol, acetonitrile and ammonium hydroxide were purchased from Kanto Chemical (Tokyo, Japan)