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Another study designed BCKDK engineered CAR-T cells for reprogramming branched chain amino acids metabolism in the tumor microenvironment based on genotype and phenotype modifications, and found significant prolongation of mouse survival, differentiation of central memory cells, and increased proportion of CAR-T cells in peripheral circulation (81)

Analytical Methods Standard biochemical analyses of plasma samples from rats were performed by routine methods in Central laboratories of University Hospital using Modular PP analyzer (Roche, Basel, Switzerland)

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CVOs can conveniently explain the POTS paradox in the hypovolemic low flow subtype (majority)