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Because were asking a cell to take messed up DNA packaging in a cell, in fact, thousands of cells if not millions eventually, and put it back to this state

Melanin is not only the primary determinant of skin colour but also protects the skin against the damaging effects of UVR [1,2]

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In brief, 200 L of a serum-free medium containing 5 10 4 cells was added to the upper chamber with the Corning BioCoat Matrigel (Corning Life Sciences, New York, USA) and allowed to invade toward the lower chamber with 10% FBS