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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

In addition to scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, Mucuna pruriens also scavenges 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals and ROS

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