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(A) Molecular structure of glutathione, (B) the extended, and (C) the folded conformations

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Our data suggest a model where, in the presence of NO, the thiol-rich environment represented by the multiple lipoate moieties of PDH-E2, acts as an intramolecular HNO generator (Fig

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Gutirrez-Carcedo P, Navaln S, Sim R, Setoain X, Aparicio-Gmez C, Abasolo I et al (2020) Alteration of the mitochondrial effects of ceria nanoparticles by gold: an approach for the mitochondrial modulation of cells based on nanomedicine