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MC4R activation in the PVN produces both the motivational component the "wanting" dimension of desire and downstream physiological responses including genital blood flow and heightened sensitivity

So for inner thighs, we typically recommend a strong laser tightening treatment with the Smartlipo system whenever any fat is removed

Christiane Bartling-Kirsch (DZNE) and Ms

Research protocols using 250mcg MT2 in the morning (to leverage circadian cortisol peaks for MC4R-mediated thermogenesis) combined with 100mcg CJC-1295/Ipamorelin before sleep (to coincide with nocturnal GH pulse) report synergistic fat loss (1520% greater than either compound alone) without appetite disruption