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Green Chem 23:18611870

32,65 Excretion of excess copper occurs primarily through the following pathways: (I) metabolized copper in the liver is incorporated into bile and subsequently excreted from the body in the form of secretory vesicles, which represents the primary mechanism for endogenous copper elimination

Cell suspensions were filtered (100 m), centrifuged (600 g, 5 min), and cultured in Endothelial Cell Medium (ECM) supplemented with 5% FBS

76,77 Consequently, the integrity of the DNA is compromised, ultimately leading to the destabilization of proteins and RNA within cells and promoting the pathological process

Anifrolumab is currently undergoing a phase 3 trial in LN (Table 2)