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Introduction Progressive segmental glomerulosclerosis or extreme loss of glomerulus filtration rate are generally acknowledged as the main characteristics of CKD [1]

The mechanisms of tissue damage in this disease are not fully understood, although it is believed that increased intracellular cystine leads to alteration of GSH levels (Levtchenko et al., 2005)

The electron donation can affect the receiving molecule in varying ways including neutralizing reactive oxygen species, or maintaining cysteine in proteins in their reduced forms

Hak A, Shinde VR, Rengan AK

doi: 10.3389/fimmu.2012.00122 232 GriffinDORothsteinTL