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Increased intestinal permeability can be a decisive step in the pathophysiological effect of dysbiosis

[DOI] [PubMed] [Google Scholar] 35.Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, McCashland TM, Shakil AO, Hay JE, Hynan L, Crippin JS, Blei AT, Samuel G, Reisch J, Lee WM

A smaller but growing body of preclinical literature investigates BPC-157 within neurological and braingut communication models

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These effects were blocked by sulfasalazine, an inhibitor of the xCT transporter, which incorporates cystine (precursor of GSH) and extrudes extracellular glutamate, an agonist of the inhibitory mGlu2/3 receptor, which lowers the synaptic glutamatergic tone