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Mitochondria serve as central regulators in this process through several key mechanisms: 2.2.1 Metabolic substrate provision Mitochondria provide not only ATP but also intermediate metabolites from the TCA cycle (e.g., citrate, succinate, -ketoglutarate) that serve as precursors for the biosynthesis of lipids, proteins, and nucleic acids, which are crucial for rapid immune cell proliferation and cytokine production (8, 9)

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Serum aspartate transaminase, alanine aminotransferase, and alkaline phosphatase, which indicate liver injury, were all reversed in the study (Figure 3

Oxidative phosphorylation is organized in a series of subsequent steps involving several redox centers distributed in five protein complexes embedded in the IMM (Sun et al., 2013