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Stomach acid with a pH between 1 and 3 attacks the peptide bonds
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
developed a dual immune checkpoint-inhibiting nanocarrier, aLS@VpNPs, which is cloaked with triple-negative breast cancer (TNBC) cell membranes and incorporates anti-LAG3 and Siglec10 proteins
Factor in the rapid clearance mechanism, whereby nasally-applied drugs are cleared with a half-life of approximately 21 minutes, and its clear why only certain peptides can be used nasally
doi: 10.1016/j.biopha.2011.04.002
