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COPD COPD is a polygenic disease with a significant epigenetic component, that there are multiple environmental risk factors (including smoking and many others) that interact and accumulate through life in complex ways, hence modulating organ development, maintenance, repair, and aging and eventually determining a range of potential lung function trajectories through life and the occurrence of early multimorbidity and premature death (Cavaills et al

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Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro