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Description
Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts
Mitwalli AH, Al-Wakeel JS, Alam A, Tarif N, Abu-Aisha H, Rashed M, et al
The enzyme is synthesized as a zymogen that undergoes intramolecular autocatalytic processing, and is secreted as a mature proteinase attached to its pro-segment (Naureckiene et al., 2003)
To determine whether variants in novel genes contribute to this disorder, we evaluated TMA metabolism by choline challenge, conducted a sensory evaluation and sequenced the exome of ten subjects with complaint of TMA-related body odor
(in prep.)
