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Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma

This is called rebound hyperpigmentation, caused by suppressed melanin suddenly over-producing

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While directly measuring neuroprotection in living patients is technically unfeasible, alternative strategies, such as monitoring pro-inflammatory markers or neuroprotective cytokines in the plasma of patients receiving istradefylline, could offer valuable mechanistic insights and serve as surrogate indicators of therapeutic activity [485]