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If the baroreflex is not set appropriately (or if the brainstem is not interpreting the signals from the baroreceptors correctly), the cardiovascular system fails to adequately respond to the fluctuating blood flow demands upon stress (like positional changes or exercise)

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Factors such as neuronal damage in the brain, inflammatory responses, oxidative stress, cell death, and altered neuroplasticity can influence depression (Malhi and Mann, 2018)

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