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En el melanocito, la activacin del receptor MC1R incrementa el AMP cclico intracelular, que estimula la enzima tirosinasa paso limitante de la melanognesis y desplaza la sntesis hacia la eumelanina, el pigmento marrn-negro responsable del oscurecimiento de la piel (bronceado)
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Gout J, Sarafian D, Mutel E, Vigier M, Rajas F, Mithieux G, et al

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[9] Paul Kendrick and Stephen Kendrick, Sarahs Long Walk: The Free Blacks of Boston and How Their Struggle for Equality Changed America (Boston: Beacon Press, 2004) 116
