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Abbreviations AAA: Abdominal aortic aneurysm ABDF: Aminosulfonyl)-7-fluoro-2,1,3benzoxadiazole ADMA: Asymmetric dimethylarginine ATP: Adenosine tri phosphate BPHL: Biphenyl hydrolase-like protein CO: Carbon monoxide CSE: Cystathionine--lyase CVD: Cardiovascular disease Cys: Cysteine CS: Cystathionine beta synthase e-NOS: Endothelial nitric oxide synthase ESRD: End stage renal disease H 2 S: Hydrogen sulfide Hcy: Homocysteine HHcy: Hyperhomocysteinemia HPLC: High performance liquid chromatography HTL: Homocysteine thiolactone IR: Insulin resistance LDL: Low density lipoprotein Lys: Lysine Met: Methionine MI: Myocardial infarction NAC: N-acetyl cysteine NO: Nitric oxide PD: Parkinsons disease PON: Paraoxonase PRMT: Protein arginine N-methyltransferase SAH: S-adenosyl-L-homocysteine SAM: S-adenosyl-L-methionine tHcy: Total homocysteine References McCully KS

New tools will reveal epithelial ecological niches and cross-kingdom interactions, guiding the discovery of novel therapeutic targets for skin diseases